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Dosage: Usually, for adults, 100 mg of trelagliptin is orally administered once a week. The score line is not intended for dose adjustment. Do not break or crush the tablet.
Special Patient Populations: Elderly Patients: Since the elderly often have reduced renal function, precautions should be taken against the onset of adverse reactions and careful administration should be performed under close observation (see Impaired Renal Function as follows, Contraindications and Pharmacology: Pharmacokinetics under Actions).
Pediatric Patients: The safety of trelagliptin tablets in low birth weight infants, neonates, nursing infants, infants and children has not been established (no clinical experience).
Impaired Renal Function: Since blood concentrations of trelagliptin may increase due to a delay in the excretions in patients with moderate renal impairment, the 100 mg dose is not recommended for patients with moderate renal impairment.
Impaired Hepatic Function: No dose adjustments are required for patients with hepatic impairment.
