Vimpat Overdosage

Symptoms: FC tab: Symptoms observed after an accidental or intentional overdose of lacosamide are primarily associated with CNS and gastrointestinal system.
The types of adverse events experienced by patients exposed to doses above 400 mg up to 800 mg were not clinically different from those of patients administered recommended doses of lacosamide.
Events reported after an intake of more than 800 mg are dizziness, nausea, vomiting, seizures (generalized tonic-clonic seizures, status epilepticus). Cardiac conduction disorders, shock and coma have also been observed. Fatalities have been reported in patients following an intake of acute single overdose of several grams of lacosamide.
Soln for infusion: There is limited clinical experience with lacosamide overdose in humans.
In clinical trials: The types of adverse events experienced by patients exposed to supratherapeutic doses were not clinically different from those of patients administered recommended doses of lacosamide.
Following doses of 1200 mg/day, symptoms related to the central nervous system (dizziness) and the gastrointestinal system (nausea) were observed and resolved with dose adjustments. The highest reported overdose for lacosamide was 12000 mg taken in conjunction with toxic doses of multiple other antiepileptic drugs. The subject was initially comatose with AV block and then fully recovered without permanent sequelae.
In post-marketing experience: Following acute single overdoses ranging between 1000 mg and 12000 mg, seizures (generalized tonic-clonic seizures, status epilepticus) and cardiac conduction disorders were observed. Fatal cardiac arrest was reported after an acute overdose of 7000 mg of lacosamide in a patient with cardiovascular risk factors.
Management: There is no specific antidote for overdose with lacosamide. Treatment of lacosamide overdose should include general supportive measures and may include haemodialysis if necessary (see Pharmacology: Pharmacokinetics under Actions).