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Adults: The usual dose is sildelnafil 50 mg about one hour before sexual intercourse. The dose may be increased or decreased depending on response. The maximum recommended dose is 100 mg, and sildenafil should not be taken more than once in 24 hours.
Elderly > 65 years: Use with caution: Starting dose of 25 mg should be considered.
Dosage considerations for patients stable on alpha-blockers: Initial 25 mg.
Dosage adjustment for concomitant use of potent CYP3A4 inhibitors: Erythromycin, itraconazole, ketoconazole: Starting dose of 25 mg should be considered.
Protease inhibitors: Maximum sildenafil dose: 25 mg every 48 hours.
Dosage adjustment in renal impairment: Clcr < 30 mL/minute: Starting dose of 25 mg should be considered.
Dosage adjustment in hepatic impairment: Child-Pugh class A and B: Starting dose of 25 mg should be considered; not studied in severe impairment (Child-Pugh class C).
Mode of Administration: Orally.
