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Use in pregnancy: Pregnancy Category B: Reproduction studies in rats and rabbits at doses up to 1 MAC have revealed no evidence of impaired fertility or harm to the fetus due to sevoflurane. There are no adequate and well-controlled studies in pregnant women, therefore, sevoflurane should be used during pregnancy only if clearly needed.
Labor and Delivery: In a clinical trial, the safety of sevoflurane was demonstrated for mothers and infants when used for anesthesia during cesarian section. The safety of sevoflurane in labor and vaginal delivery has not been demonstrated.
Use in lactation: It is not known whether sevoflurane is excreted in human milk. Caution should be exercised when sevoflurane is administered to nursing women.
