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Warning (according to Thailand's Notification of Ministry of Public Health): Contraindicated in pregnant and lactating women.
Contraindicated in patients with liver disease.
After taking this medication, if pain or ache (myalgia) developed on the calf, back or body muscles, discontinue the medication and consult the doctor.
Should have liver function tests (LFTs) performed before treatment and 6 and 12 weeks after the initiation of the treatment. Patients regularly receiving this medication should have LFTs done every 6 months or as advised by a doctor. If transaminase level is higher than 3x upper normal limit, discontinue the medication and consult a doctor.
Use with caution when co-administered with digoxin and warfarin, because blood levels of these drugs may be increased to harmful levels.
Risk of myopathy and rhabdomyolysis will be increased when statins are concomitantly used with the following medications: azole antifungals (e.g., ketoconazole, itraconazole); macrolides (e.g., erythromycin, clarithromycin); HIV protease inhibitors (e.g., indinavir, ritonavir, nelfinavir, saquinavir); verapamil; diltiazem; gemfibrozil; nicotinic acid; cyclosporine; amiodarone.
Risk of rhabdomyolysis is increased in the following conditions: using high dosage, elderly, hepatic/renal impairment, chronic alcoholism, hypothyroidism etc.
Use with caution when co-administered with colchicine especially in the elderly or in patients with impaired renal function because of the risk of myopathy or rhabdomyolysis.
This medicine may increase the risk of having increased blood sugar levels.
