As monotherapy or in combination w/ levodopa for idiopathic Parkinson's disease. Symptomatic treatment of idiopathic restless legs syndrome.
Dosage/Direction for Use
Parkinson's disease0.125 mg Initially 0.125 mg tid. Slowly titrate, not more frequently than every 5-7 days for 7 wk to achieve optimal response. 0.25 & 1 mg Initially 0.375 mg daily in 3 divided doses, then increase gradually to 0.125 mg/dose every 5-7 days. Range: 1.5-4.5 mg daily. Restless legs syndrome 0.125 mg once daily 2-3 hr before bedtime. Increase every 4-7 days. Max: 0.125 mg 0.5 mg/day. 0.25 & 1 mg 0.75 mg/day.
Administration
May be taken with or without food: May be taken w/ meals to reduce GI side effects.
Contraindications
Hypersensitivity.
Special Precautions
Renal impairment. Hallucinations & confusion. Orthostatic hypotension may occur; risk of hypotension or poorly tolerated transient hypotensive episodes. May impair ability to drive or operate machinery. 0.125 mg: Melanoma, rhabdomyolysis, somnolence. New or worsening dyskinesia. Restless leg syndrome rebound & augmentation. Impulse control & compulsive behaviors or hallucinations. Fibrotic complications (peritoneal fibrosis, pleural fibrosis & pulmonary fibrosis)
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