Piptam Drug Interactions

Non-depolarizing muscle relaxants: prolonged neuromuscular blockade has been reported when vecuronium was used concomitantly with Piperacillin. Due to their similar mechanism of action.
Probenecid: prolongs the half-life of Piperacillin/Tazobactam by 21% and 71% respectively and lower renal clearance for both piperacillin and tazobactam. However, peak plasma concentrations of either drug are unaffected.
Methotrexate: Piperacillin may decrease renal clearance of methotrexate, frequent monitoring of serum methotrexate concentrations should be performed, and patients should be monitored for signs and symptoms of methotrexate toxicity.
Aminoglycosides: the antibacterial activity of Piperacillin and aminoglycosides is synergistic in vitro against some Enterobacteriaceae and Pseudomonas aeruginosa. Concomitant use of aminoglycosides and Piperacillin in patients with end stage renal disease (ESRD) requiring hemodialysis substantially alters serum concentrations of the aminoglycoside, should be closely monitoring serum concentration of aminoglycoside.
Anticoagulants: coagulation parameters should be monitored more frequently after concomitantly with high doses of heparin, oral anticoagulants, or other drugs that affect blood coagulant or thrombocyte function.
Vancomycin: the risk of vancomycin-induced nephrotoxicity may increase due to an interaction with Piperacillin/Tazobactam. No pharmacokinetic interactions have been reported between Piperacillin/Tazobactam and vancomycin.
Laboratory test interferences: Tests for urinary glucose: the administration of Piperacillin/Tazobactam may result in a false-positive reaction for glucose in the urine using a copper-reduction method. Glucose oxidase tests for urinary glucose are recommended.
Test for Aspergillus: False-positive test results for Aspergillus were reported when the Bio-Red Laboratories Platelia Aspergillus EIA in patients receiving Piperacillin/Tazobactam injection. Positive Platelia Aspergillus EIA test results in patients receiving Piperacillin/Tazobactam should be interpreted with caution and confirmed by other diagnostic methods.