Monotherapy or in combination w/ sulfonylurea, metformin or insulin for NIDDM.
Dosage/Direction for Use
15 or 30 mg once daily, may be increased up to 45 mg once daily.
Administration
May be taken with or without food.
Contraindications
Heart failure (NYHA class III or IV). Pregnancy, lactation. Childn <18 yr.
Special Precautions
May result in ovulation in some premenopausal anovulatory women. Fluid retention can occur when used w/ other antidiabetic agents. Discontinue if any deterioration in cardiac status occurs. Evaluate serum ALT levels prior to initiation of therapy & periodically thereafter. Higher incidence of bone fractures in females. New onset or worsening of diabetic macular edema w/ decreased visual acuity have occurred during use.
Adverse Reactions
URTI, headache, sinusitis, myalgia, tooth disorder, aggravation of DM, pharyngitis; mild to moderate anemia & edema in combination w/ sulfonylurea, metformin or insulin; dyspnea & wt gain in combination w/ insulin; elevations in CPK levels; hypoglycemia in combination w/ sulfonylurea or insulin.
Sign Out
