Ossobon-D Mechanism of Action

Pharmacology: Pharmacodynamics: Ossobon-D contains the vitamin D and the ossein mineral components of bone tissue in the physiological proportions, including calcium and phosphate, trace elements, fluoride and other ions, proteins, and glycosaminoglycans. It is given orally to patients requiring both calcium and phosphorus supplementation.
The anti-osteoporotic activity of Ossobon-D is based on a dual effect: An anabolic effect on osteoblast and an anticatabolic effect on osteoclasts. These 2 different types of action are physiologically complementary: Balance bone resorption and bone formation or bone remodeling.
Pharmacokinetics: Vitamin D substance are well absorbed from the gastrointestinal tract, absorption may be decreased in patients with decreased fat absorption.
Vitamin D compounds are hydroxylated first in the liver and further in the kidney, hydroxylation of cholecalciferol form the active metabolites. Vitamin D compounds and their metabolites are excreted mainly in the bile and faeces with only small amount appearing in urine. Certain vitamin D substances may be distributed into breast milk. Vitamin D may accumulate in fat tissue and muscle for a long time. Cholecalciferol has a slow-acting effect but a long duration of action.