Short-term treatment of HTN when oral therapy is not feasible or not desirable.
Dosage/Direction for Use
Slow continuous IV infusion at a conc of 0.1 mg/mL. Gradual reduction in BP Initially 50 mL/hr (5 mg/hr). If desired BP reduction is not achieved at this dose, infusion rate may be increased by 25 mL/hr (2.5 mg/hr) 15 min or every 5 min for more rapid BP reduction up to a max of 150 mL/hr. Following achievement of the BP goal, the infusion rate should be decreased to 30 mL/hr (3 mg/hr). Hypotension or tachycardia Infusion may be restarted at low doses eg, 30-50 mL/hr (3-5 mg/hr) & adjusted to maintain desired BP when BP has stabilized.
Contraindications
Hypersensitivity. History of acute heart failure, advanced aortic stenosis. Neonates.
Special Precautions
CHF or impaired hepatic or renal function. Coronary ischemia. Increased angina upon initiation of therapy. Monitor BP during & after infusion. Avoid abrupt or excessive reduction in BP during therapy. Pregnancy & lactation. Childn < 2 yr.
C08CA04 - nicardipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.
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