Adult 5 mg/day on the 1st wk, 10 mg/day on the 2nd wk, then 15 mg/day on the 3rd wk. From the 4th wk on, treatment can be continued w/ the recommended maintenance dose of 20 mg/day. Max: 20 mg/day. Elderly 20 mg/day (10 mg bid or 20 mg once daily).
Administration
May be taken with or without food.
Contraindications
Hypersensitivity to memantine.
Special Precautions
Epilepsy. Co-administration w/ NMDA-antagonists (eg, amantadine, ketamine or dextromethorphan). Careful monitoring of patients w/ factors that may raise urine pH. Recent MI, uncompensated CHF, uncontrolled HTN. Pregnancy & lactation.
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