Mecolzine Dosage/Direction for Use

Posology: Ulcerative colitis: Adults and elderly: Depending upon the clinical requirements in individual cases, the following daily doses are recommended: For the treatment of acute episodes of ulcerative colitis: 1.5 g to 3.0 g mesalazine in three divided doses (1 or 2 tablets of Mecolzine 500 mg three times daily).
For the prevention of recurrence/long term treatment of ulcerative colitis: 1.5 g mesalazine in three divided doses (1 tablet of Mecolzine 500 mg three times daily).
Paediatric population: There is only limited documentation for an effect in children (age 6-18 years).
Children 6 years of age and older: For the treatment of acute episodes: to be determined individually, starting with 30-50 mg/kg/day in divided doses. Maximum dose: 75 mg/kg/day. The total dose should not exceed the maximum adult dose. Do not crush, divide or chew the tablets.
For the prevention of recurrence/long term treatment of ulcerative colitis: To be determined individually, starting with 15-30 mg/kg/day in divided doses. The total dose should not exceed the recommended adult dose. Do not crush, divide or chew the tablets.
It is generally recommended that half the adult dose may be given to children up to a body weight of 40 kg; and the normal adult dose to those above 40 kg.
Crohn's disease: Adults: Depending upon the clinical requirements in individual cases, the following daily doses are recommended: For the treatment of acute episodes of Crohn's disease: 1.5 g to 4.0 g mesalazine in three divided doses (1 to 3 tablets of Mecolzine 500 mg three times daily).
Method of administration: Mecolzine 500 mg tablets should be taken in the morning, at midday and in the evening, 1 hour before meals. They should be swallowed whole, not chewed, and taken with plenty of fluid.
Treatment with Mecolzine 500 mg tablets should be administered regularly and consistently, both in the acute inflammatory stage and during maintenance therapy in order to achieve the desired therapeutic effect.
The duration of use is determined by the physician.
For maintenance of remission in ulcerative colitis, the dose can usually be reduced to 1.5 g mesalazine/day (adults and adolescents with a body weight over 40 kg) and 0.75 g mesalazine/day (children/adolescents).