Isobinate Dosage & Drug Information

Concise Prescribing Info

Contents

Isosorbide dinitrate

Indications/Uses

Treatment & prevention of angina pectoris, coronary insufficiency.

Dosage/Direction for Use

Maintenance: 1-4 tab 6 hrly. Treatment: ½ to 1 tab 6 hrly.

Administration

Should be taken on an empty stomach: Take 30 min before meals.

Contraindications

Severe anemia; marked hypotension; head trauma, cerebral hemorrhage, increased intracranial pressure; acute MI. Avoid sildenafil, tadalafil & vardenafil.

Special Precautions

Closed-angle glaucoma. May develop tolerance & cross-tolerance to other nitrates & nitrites.

Adverse Reactions

Headache; flushing, dizziness; palpitations; orthostatic hypotension, tachycardia; vertigo; confusion; weakness.

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Drug Interactions

Hypotensive effect enhanced by alcohol, β-blockers, antihypertensives, TCAs, narcotics, sildenafil, tadalafil, vardenafil. May potentiate effects of antihistamines, anticholinergics. Antagonises pressor action of sympathomimetics.

MIMS Class

Anti-Anginal Drugs

ATC Classification

C01DA08 - isosorbide dinitrate ; Belongs to the class of organic nitrate vasodilators. Used in the treatment of cardiac disease.

Thai FDA Category

Presentation/Packing

Form

Isobinate tab 10 mg

Packing/Price

500's

Isobinate

isosorbide dinitrate

Manufacturer:

General Drugs House

Distributor:

General Drugs House