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Patients with a known hypersensitivity to irinotecan, topotecan, or other camptothecin analogues or hypersensitivity to one of the excipients of irinotel.
Pregnancy and lactation.
Patients with chronic inflammatory bowel disease and/or bowel obstruction.
Patients with a bilirubin more than 3 times the upper limit of the normal range.
Patients with severe bone marrow failure; Patients with who performance status more than 2.
