Individualized dosage.
Infusion Prophylaxis of bleeding Usual dose: 20-40 IU factor VIII/kg body wt administered at 2-3 days intervals.
Early haemarthrosis, muscle or oral bleeding 20-40 IU factor VIII/dL. Repeat every 12-24 hr for at least 1 day until bleeding is resolved.
More extensive haemarthrosis, muscle bleeding or haematoma 30-60 IU factor VIII/dL. Repeat every 12-24 hr for 3-4 days until pain & acute disability are resolved.
Life-threatening haemorrhages 60-100 IU factor VIII/dL. Repeat every 8-24 hr until threat is resolved.
Minor surgery including tooth extraction 30-60 IU factor VIII/dL every 24 hr, at least 1 day, until healing is achieved.
Major surgery 80-100 IU factor VIII/dL (pre- & post-op). Repeat every 8-24 hr until adequate wound healing then continue for at least 7 days to maintain factor VIII at 30-60% (IU/dL).