Gansulog Special Precautions

Severe, life-threatening allergic reactions, including anaphylaxis may occur. If hypersensitivity reactions occur, discontinue therapy.
Use with caution and monitor blood glucose closely in renal or hepatic impairment due to changes in insulin clearance metabolism.
Hypoglycemia is the most common adverse effect of insulin. Hypoglycemia may result from increased work or exercise without eating.
Insulin requirements may be altered during illness, emotional disturbances or other stressors. Instruct patients to use caution with ethanol; may increase risk of hypoglycemia. Insulin may produce hypokalemia which, if left untreated, may result in respiratory paralysis, ventricular arrhythmia and even death.
Insulin glargine is a clear solution, but it is NOT intended for IV or IM administration or via an insulin pump.
Patients must be instructed to perform continuous rotation of the injection site to reduce the risk of developing lipodystrophy and cutaneous amyloidosis. There is a potential risk of delayed insulin absorption and worsened glycemic control following insulin injections at sites with these reactions. A sudden change in the injection site to an unaffected area has been reported to result in hypoglycemia. Blood glucose monitoring is recommended after the change in the injection site, and dose adjustment of antidiabetic medications may be considered.
Effects on ability to drive and use machines: The patient's ability to concentrate and react may be impaired as a result of hypoglycemia or hyperglycemia or, for example, as a result of visual impairment. This may constitute a risk in situations where these abilities are of special importance (e.g. driving a car or using machines).
Patients should be advised to take precautions to avoid hypoglycemia whilst driving. This is particularly important in those who have reduced or absent awareness of the warning symptoms of hypoglycemia or have frequent episodes of hypoglycemia. It should be considered whether it is advisable to drive or use machines in these circumstances.