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Pregnancy: Category D.
Based on animal data and its mechanism of action, etoposide can cause fetal harm when administered to a pregnant woman. Etoposide is teratogenic in mice and rats. Advise pregnant women of the potential hazard to a fetus.
Advise women of childbearing potential to avoid becoming pregnant.
Nursing mothers: There is no information regarding the presence of etoposide in human milk or its effects on breastfed infant milk production. Because of the potential for serious adverse reactions in nursing infants from etoposide, advise women not to breastfeed during treatment with etoposide.
