In combination w/ other antiretrovirals for HIV-1 infection. HBV infection.
Dosage/Direction for Use
300 mg once daily.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity.
Special Precautions
Patients w/ hepatic disease. Closely monitor renal function in patients w/ renal impairment. Patients w/ CrCl <50 mL/min. Discontinue in case of lactic acidosis & severe hepatomegaly w/ steanosis. Not used as monotherapy in HIV infection.
Adverse Reactions
Chest pain, anxiety, headache, pain, fever, insomnia, rash including maculopapular, pustular or vesiculobullous rash, urticaria. GI disturbance eg, dyspepsia, nausea, vomiting, diarrhea. Lactic acidosis, hepatitis, increased liver enzymes.
Didanosine, adefovir, dabigatran etexilate, vincristine. May increase conc of aminoglycosides, darunavir, didanosine, ganciclovir-valganciclovir. Conc may be increased by acyclovir-valacyclovir, adefovir, atazanavir, NSAIDs.
J05AF07 - tenofovir disoproxil ; Belongs to the class of nucleoside and nucleotide reverse transcriptase inhibitors. Used in the systemic treatment of viral infections.
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