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Pharmacodynamics: Deferasirox is an orally active chelating agent that is selective for iron (III) with a high affinity binding ratio of 2:1. Iron excretion produced by deferasirox is primarily fecal.
Pharmacokinetics: Absorption: Time to peak, plasma ~1.5 to 4 hours.
Bioavailability: 70%.
Distribution: Volume of distribution: Adults: 14.4 ± 2.7 L.
Protein binding: ~ 99% to serum albumin.
Metabolism: Hepatic via glucuronidation by UGT1A1 (primarily) and UGT1A3; minor oxidation by CYP450 (approximately 8%); undergoes enterohepatic recirculation.
Half-life elimination: 8 to 16 hours.
Excretion: Feces (84%), urine (8%).
Moderately lower (by 17.5%) in women than in men.
