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Overdose: In addition to diuresis and resultant dehydration, overdose of thiazides may produce lethargy, nausea, weakness, electrolyte imbalance; lethargy may progress to coma within a few hours with minimal depression of respiratory and cardiovascular function and without evidence of dehydration or serum electrolyte changes. GI irritation and hypermotility may occur, and temporary elevation of the BUN has been reported. Serum electrolyte changes (e.g., hypokalemia, hypochloremia, hyponatremia) may occur, especially in patients with impaired renal function.
Treatment: Gastric contents may be evacuated. If the patient is conscious, induction of vomiting with ipecac syrup is effective in remove the drug from the stomach. Treatment is generally supportive. Serum electrolytes and renal function should be monitored and replacement of fluid and electrolytes may be indicated. GI irritation is usually of short duration but may be treated symptomatically.
