Adult/elderly Initially 5 mg once daily. May be increased to 10 mg daily after at least 4-6 wk of clinical assessment in patients who tolerated treatment at 5 mg daily. Max dose: 10 mg daily.
May exaggerate succinylcholine-type muscle relaxation during anesth. Patients w/ sick-sinus syndrome, supraventricular cardiac conduction conditions eg, SA or AV block. History of ulcer disease; asthma or obstructive pulmonary disease. May exacerbate or induce extrapyramidal symptoms. Bladder outflow obstruction. Concurrent use w/ NSAIDs. Avoid concomitant use w/ inhibitors of acetylcholinesterase, agonists or antagonists of cholinergic system. May affect ability to drive or operate machinery. Severe hepatic impairment. Pregnancy & lactation. Not recommended in childn.
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