Canditral Drug Interactions

Coadministration of Terfenadine with CANDITRAL has led to elevated plasma concentrations of terfenadine, resulting in rare instances of life threatening cardiac dysrythmias. CANDITRAL when compared to Ketoconazole has a less pronounced effect on the biotransformation system responsible for the metabolism of Astemizole. Based on the chemical resemblance of Itraconazole and Ketoconazole, Coadministration of Astemizole with CANDITRAL is contraindicated.
Co-administration of CANDITRAL and cyclosporine or digoxin increases plasma concentration of latter two drugs and the concentrations of cyclosporine and digoxin should be monitored frequently and dose adjustment as necessary.
When CANDITRAL is coadministered with phenytoin, rifampicin or H₂ antagoists, plasma concentrationsof CANDITRAL are reduced.
CANDITRAL enhances the anticoagulant effect of coumarin drugs.
Plasma concentrations of CANDITRAL are reduced when it is coadministered with isoniazid. Itraconazole plasma concentrations should be monitored when CANDITRAL and isoniazid is coadministered.
Severe hypoglycemia has been reported in patients concomitantly receiving azole antifungal agents and oral hypoglycemic agents. Blood glucose concentrations should be carefully monitored when CANDITRAL and oral hypoglycemic agents are coadministered.