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Irbesartan can be used along with other anti-hypertensive agents; for such, β-blockers, calcium channel blocker and thiazide diuretic, for synergistic effect. However, the treatment of high dose diuretic may result in volume depletion and a risk of hypotension and therefore it should be used with caution.
The use of Irbesartan with potassium-sparing diuretic; such as, spironolactone, triamterene, amiloride potassium supplements may increase serum potassium level. Therefore avoid coadministration of these agents.
Coadministration of Irbesartan and lithium will increase lithium concentration resulting in toxicities. Therefore, this combination is not recommended. If the therapy is necessary, a close monitoring of lithium level is advised.
Administration of Irbesartan simultaneously with NSAIDs may reduce anti-hypertensive efficacy and worsen renal function, including acute renal failure. Moreover, it will increase serum potassium level, especially, in patients with history of renal function impairment.
