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Overdose: Overdose following clopidogrel administration may lead to prolonged bleeding time and subsequent bleeding complications.
A single oral dose of clopidogrel at 1500 or 2000 mg/kg was lethal to mice and to rats and at 3000 mg/kg to baboons. Symptoms of acute toxicity were vomiting (in baboons), prostration, difficult breathing, and gastrointestinal hemorrhage in all animals.
Recommendations about Specific Treatment: Based on biological plausibility, platelet transfusion may be appropriate to reverse the pharmacological effects of clopidogrel bisulfate if quick reversal is required.
