Slow IV infusion Mucosal & cutaneous herpes simplex (HSV-1 & HSV-2) infections Immunocompromised patients: Adult 5 mg/kg infused at a constant rate over 1 hr every 8 hr (15 mg/kg/day) for 7 days.
Childn <12 yr 250 mg/m
2 by infusion at a constant rate over 1 hr every 8 hr for 7 days.
Herpes simplex encephalitis 10 mg/kg infused at a constant rate over at least 1 hr every 8 hr for 10 days.
Childn 6 mth & 12 yr 500 mg/m
2 infused at a constant rate over at least 1 hr every 8 hr for 10 days.
Varicella zoster infections Immunocompromised patient 10 mg/kg infused at a constant rate over 1 hr every 8 hr for 7 days.
Childn <12 yr 500 mg/m
2 at a constant rate over at least 1 hr every 8 hr for 7 days.
Obese patient 10 mg/kg. Max: 500 mg/m
2 every 8 hr.
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