Initially 1 tab tds. Up or down titrate in increments of 500 mg daily as needed every 1-2 wk until acceptable serum P level is reached w/ regular monitoring afterwards. Max: 6 tab daily.
Patients w/ peritonitis, significant GI or hepatic disorders & those w/ major GI surgery. Not to be taken by patients w/ rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrose-isomaltase insufficiency. Patients w/ diabetes (1 tab is equiv to approx carbohydrates 1.4 g). May cause discoloured (black) stool. Perform careful assessment of benefit/risk & periodic clinical monitoring of Fe parameters when administered concomitantly w/ oral or IV Fe supplementation. Patients w/ earlier stages of renal impairment. Severe hepatic impairment. Pregnancy & lactation. Childn <18 yr.
Alendronate, atorvastatin, doxercalciferol, doxycycline (should be taken at least 1 hr before Velphoro), levothyroxine (not to be prescribed w/ Velphoro) & paricalcitol. May affect bioavailability of other medicinal products; consider separate administration w/ oral medications where bioavailability reduction would have a clinically significant effect on its safety or efficacy. Concomitant treatment w/ medicinal products w/ narrow therapeutic window; monitor clinical effect & adverse events.
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