Diclofenac has been reported to increase plasma concentrations of lithium by impairing its renal excretion. It has been also reported to increase plasma concentrations of digoxin, but no clinical signs of overdosage have been encountered. Various non-steroidal anti-inflammatory agents are liable to inhibit the activity of diuretic and to potentiate the effects of potassium-sparing diuretic, thus making it necessary to monitor serum potassium levels. Caution should be exercised if diclofenac and methotrexate are administered within 24 hours of each other since NSAIDs may increase methotrexate plasma levels, resulting in increased toxicity. Diclofenac has been reported to lower salicylate concentrations and vice versa.
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