Hyperthyroidism especially in slight or absent thyroid enlargement. Prep for surgery in all forms of hyperthyroidism; patients w/ hyperthyroidism for radioiodine treatment. Intermittent treatment after radioiodine therapy. Long-term hyperthyroidism therapy in exceptional cases where definite therapeutic measures are not applicable due to patient's general condition. Prophylactic treatment in patients w/ history of hyperthyroidism & autonomous adenomas in whom iodine exposure is indispensable (eg, exam w/ iodine-containing contrast media).
AdultMild case of hyperthyroidism Initially 20 mg daily. Inhibition of thyroid hormone production 25-40 mg daily. Severe case of hyperthyroidism Initially 40 mg daily. Maintenance: Combination w/ levothyroxine: 5-20 mg daily; Monotherapy: 2.5 & 10 mg daily. Long-term antithyroid therapy 2.5-10 mg/day. Prophylactic treatment in patients w/ history of hyperthyroidism & autonomous adenomas in whom iodine exposure is indispensable 10-20 mg daily &/or perchlorate 1 g are administered for approx 10 days (eg, for renally excreted contrast media). Childn Initially 0.3-0.5 mg/kg/day. After normalization of thyroid function, dose may be gradually reduced to 0.2-0.3 mg/kg/day.
View Thyrozol overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food.
Contraindications
Hypersensitivity to thiamazole, other thionamide derivatives. Moderate to severe blood count disturbances (granulocytopenia). Preexisting cholestasis not caused by hyperthyroidism. Previous damage to bone marrow; history of acute pancreatitis after treatment w/ carbimazole or thiamazole. Combination therapy w/ thiamazole & thyroid hormones during pregnancy.
Not to be used in patients w/ history of mild hypersensitivity reactions (eg, allergic rashes, pruritus). Avoid long-term treatment & monitor patients w/ large goitres. Agranulocytosis; closely monitor blood count before & after initiation of therapy especially in cases w/ pre-existing mild granulocytopenia. Discontinue treatment if bone marrow damage occurs. Discontinue immediately in case of acute pancreatitis. Discontinue therapy & initiate appropriate intervention if vasculitis is suspected. Reduce dose as soon as a eurothyroid metabolic condition is achieved. Goiter growth under therapy. Inform patients that their energy consumption normalizes along w/ the improving clinical picture. Contains lactose; not to be taken by patients w/ hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption. Closely monitor & the dose should be kept as low as possible in patients w/ hepatic & renal impairment. Women of childbearing potential must use effective contraceptive measures during treatment. Pregnancy & lactation. Elderly.
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