Neuropathic pain Initially, 150 mg daily given as 2 or 3 divided doses. May be increased to 300 mg daily after 3-7 day interval. Max: 600 mg daily after an additional 7-day interval.
Epilepsy Initially, 150 mg daily given as 2 or 3 divided doses. May be increased to 300 mg daily after 1 wk. Max: 600 mg daily after an additional wk.
GAD Initially, 150 mg daily given as 2 or 3 divided doses. May be increased to 300 mg daily after 1 wk & 450 mg daily following an additional wk. Max: 600 mg daily after an additional wk.
Fibromyalgia Initially, 75 mg bd. May be increased to 150 mg bd w/in 1 wk or if needed, further increased to 225 mg bd. Max: 450 mg daily.
Renal impairment: CrCl ≥60 mL/min Initially, 150 mg daily bd or tds. Max: 600 mg daily bd or tds,
≥30-<60 mL/min Initially, 75 mg daily bd or tds. Max: 300 mg daily bd or tds,
≥15-<30 mL/min Initially, 25-50 mg once daily or bd. Max: 150 mg once daily or bd,
<15 mL/min Initially, 25 mg once daily. Max: 75 mg once daily.
Haemodialysis Supplementary dose: 25 mg (max: 100 mg).
Sign Out
