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Indications and Dosage
Oral
Gastric ulcer Adult: 100 mg tid, usually in the morning, evening and before bedtime. Oral NSAID-induced enteropathy, NSAID-induced gastropathy Adult: 100 mg tid. Treatment recommendations may vary among individual products and between countries (refer to specific product guidelines). Oral Gastric mucosal lesions Adult: In cases associated with acute gastritis or acute exacerbation of chronic gastritis: 100 mg tid.
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Administration
May be taken with or without food.
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Special Precautions
Elderly. Pregnancy and lactation.
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Adverse Reactions
Significant: Anaphylactoid reactions, shock; thrombocytopenia, leucopenia; jaundice, hepatic dysfunction.
Gastrointestinal disorders: Nausea, vomiting, dry mouth, constipation, diarrhoea, abdominal pain, sensation of abdominal enlargement, belching, heartburn, taste abnormality. Investigations: Increased AST, ALT, alkaline phosphatase or BUN levels. Nervous system disorders: Dizziness, drowsiness, numbness. |
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Action
Description:
Mechanism of Action: Rebamipide increases the prostaglandin E2 in the gastric mucosa and elevates gastric mucous, gastric mucosal blood flow and secretion of gastric alkaline. Additionally, it stimulates gastric mucosal cell growth and decreases gastric mucosa injury. Pharmacokinetics: Absorption: Time to peak plasma concentration: 2 hours. Distribution: Plasma protein binding: 98.4-98.6%. Metabolism: Minimally metabolised in the liver. Excretion: Via urine (approx 10% as unchanged drug). Elimination half-life: Approx 1.5 hours. |
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Chemical Structure
 Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 5042, Rebamipide. https://pubchem.ncbi.nlm.nih.gov/compound/Rebamipide. Accessed Mar. 26, 2024. |
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Storage
Store below 30°C.
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MIMS Class
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ATC Classification
A02BX14 - rebamipide ; Belongs to the class of other drugs used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).
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References
Anon. Rebamipide. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 05/02/2024. Buckingham R (ed). Rebamipide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/02/2024. Mucopid 100 mg Film-coated Tablet (BCWorld Pharm. Co., Ltd.). MIMS Philippines. http://www.mims.com/philippines. Accessed 05/02/2024. Mucopro (Kyung Dong Pharm. Co., Ltd.). MIMS Philippines. http://www.mims.com/philippines. Accessed 05/02/2024. Mucoprotec 100 mg Film-coated Tablet (Kyung Dong Pharm. Co., Ltd.). MIMS Philippines. http://www.mims.com/philippines. Accessed 15/03/2024. Mucosta 100 mg Tablet (Otsuka [Philippines] Pharmaceutical, Inc.). MIMS Philippines. http://www.mims.com/philippines. Accessed 15/03/2024. Mucosta Tablets 100 mg (A. Menarini Singapore Pte. Ltd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 05/02/2024. Ramiper Film-coated Tablet (Sanbe Farma PT). MIMS Indonesia. http://www.mims.com/indonesia. Accessed 05/02/2024.
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