Turbuhaler: Acute overdose with Pulmicort Turbuhaler, even in high doses, is not expected to cause any clinical problems. If used chronically in high doses, systemic effects of glucocorticosteroids such as hypercortisolism and adrenal suppression can occur.
Respules: Symptoms: In most cases, occasional overdosing will not produce any obvious symptoms but will decrease the plasma cortisol level and increase the number and percentage of circulating neutrophils. The number and percentage of lymphocytes and eosinophils will decrease concurrently. Habitual overdosing may cause hypercorticism and hypothalamic-pituitary-adrenal suppression.
Treatment: Withdrawing PULMICORT or decreasing the dose will abolish these effects, although the normalization of the HPA-axis may be a slow process.