ProQuad Dosage/Direction for Use

Dosage: Individuals 12 months through 12 years of age should receive a single dose of ProQuad administered subcutaneously.
A second dose of measles-containing vaccine should be administered according to the Singapore's national immunization program.
At least 1 month should elapse between a dose of M-M-R II and a dose of ProQuad. If a second dose of varicella-containing vaccine is administered, there should be a minimum interval of 3 months between doses.
Do not give immune globulin (IG) or Varicella-Zoster Immune Globulin (VZIG) concomitantly with ProQuad (see INTERACTIONS).
Method of Administration: FOR SUBCUTANEOUS ADMINISTRATION. DO NOT INJECT INTRAVASCULARLY.
The vaccine is to be injected in the deltoid region of the upper arm or in the higher anterolateral area of the thigh.
CAUTION: A sterile syringe free of preservatives, antiseptics, detergents, and other antiviral substances must be used for each injection and/or reconstitution of ProQuad because these substances may inactivate the vaccine viruses.
To reconstitute the vaccine, use only the diluent supplied because it is free of preservatives or other antiviral substances, which might inactivate the vaccine viruses.
It is important to use a separate sterile syringe and needle for each patient to prevent transmission of infectious agents from one individual to another.
Withdraw the entire volume of solvent into a syringe (if a prefilled syringe is available, this step is not necessary). Inject the entire content of the syringe into the vial containing the powder. Gently agitate to dissolve completely. Withdraw the entire content of the reconstituted vaccine from the vial into the same syringe and inject the entire volume.
IT IS RECOMMENDED THAT THE VACCINE BE ADMINISTERED IMMEDIATELY AFTER RECONSTITUTION, TO MINIMIZE LOSS OF POTENCY. DISCARD IF RECONSTITUTED VACCINE IS NOT USED WITHIN 30 MINUTES.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Before reconstitution, the lyophilized vaccine is a white to pale yellow compact crystalline plug. ProQuad, when reconstituted, is a clear pale yellow to light pink liquid.