Pantobex Dosage/Direction for Use

20 mg tablet: Mild reflux disease and associated symptoms (e.g. heartburn, acid regurgitation, pain on swallowing): The recommended oral dosage is one pantoprazole 20 mg gastro-resistant tablet per day. Symptom relief is generally accomplished within 2-4 weeks, and a 4-week treatment period is usually required for healing of associated oesophagitis.
Long-term management and prevention of relapse in reflux oesophagitis: For long-term management, a maintenance dose of one pantoprazole 20 mg gastro-resistant tablet per day is recommended, increasing to 40 mg pantoprazole per day if a relapse occurs.
Prevention of gastroduodenal ulcers induced by non-selective, non-steroidal anti-inflammatory drugs (NSAIDs) in patients at risk with a need for continuous NSAID treatment: The recommended oral dosage is one pantoprazole 20 mg gastro-resistant tablet per day.
Pantoprazole 20 mg gastro-resistant tablet must not be split, chewed or crushed, and should be swallowed whole with water 1 hour before a meal.
Special populations: Hepatic impairment: A daily dose of 20 mg pantoprazole should not be exceeded in patients with severe liver impairment.
Renal impairment: No dose adjustment is necessary in elderly patients or in those with impaired renal function.
40 mg tablet: The recommended dosage in duodenal ulcer, gastric ulcer and reflux oesophagitis is one gastro-resistant tablet per day. Pantoprazole 40 mg gastro-resistant tablet must not be split, chewed or crushed, and should be swallowed whole with water 1 hour before a meal.
Duodenal ulcer: Duodenal ulcers generally heal within 2 weeks. If a 2-week period of treatment is not sufficient, healing will be achieved in almost all cases within a further 2 weeks.
Gastric ulcer: A 4-week period is usually required for the treatment of gastric ulcers. If this is not sufficient, healing will usually be achieved within a further 4 weeks.
Moderate and severe reflux oesophagitis: A 4-week period is usually required for the treatment of reflux oesophagitis. If this is not sufficient, healing will usually be achieved within a further 4 weeks.
Elderly: No dose adjustment is necessary in the elderly. However, the daily dose of 40 mg pantoprazole should not be exceeded.
Patients with impaired renal function: No dose adjustment is necessary in patients with impaired renal function. However, the daily dose of 40 mg pantoprazole should not be exceeded.
Hepatic Impairment: In patients with severe liver impairment the dose has to be reduced to 1 tablet every other day. Furthermore, in these patients the liver enzymes should be monitored during pantoprazole therapy. In the case of a rise of the liver enzymes, pantoprazole should be discontinued.
Children: There is no information on the use of pantoprazole in children. Therefore pantoprazole tablets should not be used in children.