Ovidrel

Ovidrel

choriogonadotropin alfa

Manufacturer:

Merck

Distributor:

Apex Pharma Marketing
Concise Prescribing Info
Contents
Choriogonadotropin α
Indications/Uses
Women undergoing superovulation prior to assisted reproductive technologies (ART) to trigger final follicular maturation & luteinisation after stimulation of follicular growth. Anovulatory or oligo-ovulatory women to trigger ovulation & luteinisation in anovulatory or oligo-ovulatory patients after stimulation of follicular growth.
Dosage/Direction for Use
SC Women undergoing superovulation prior to ART 250 mcg 24-48 hr after the last administration of FSH or human menopausal gonadotropin prep, when optimal follicular growth stimulation is achieved. Anovulatory or oligo-ovulatory women 250 mcg 24-48 hr after optimal follicular growth stimulation is achieved. Recommended to have coitus on the day of, & the day after inj.
Contraindications
Hypersensitivity. Hypothalamic & pituitary gland tumours. Ovarian enlargement or cyst unrelated to PCOS. Gynaecological haemorrhages of unknown aetiology. Ovarian, uterine or mammary carcinoma. Active thromboembolic disorders. Not to be used in conditions when an effective response cannot be obtained eg, primary ovarian failure, sexual organ malformations & fibroid uterine tumours incompatible w/ pregnancy, & postmenopausal women.
Special Precautions
Evaluate patients for hypothyroidism, adrenocortical deficiency, hyperprolactinemia, pituitary or hypothalamic tumours. Patients w/ clinically significant systemic diseases where pregnancy could lead to worsening of the condition. Possible ovarian hyperstimulation syndrome (OHSS); monitor stimulation cycles by ultrasound scans & estradiol measurements to early identify risk factors. Increased incidence of multiple pregnancy & births; pregnancy loss by miscarriage or abortion. Increased risk for ectopic pregnancy in women w/ history of tubal disease. Slightly higher prevalence of congenital malformations after ART. Women w/ recent thromboembolic disease or those w/ generally recognised risk factors for thromboembolic events (eg, personal or family history). Possible ovarian & other reproductive system neoplasms. May potentially lead to a false +ve pregnancy test; may interfere w/ immunological determination of serum or urinary HCG for up to 10 days. Contains Na <1 mmol/dose. No indication for use during pregnancy. Not indicated during breastfeeding.
Adverse Reactions
Headache; abdominal pain & distension, nausea, vomiting; mild or moderate OHSS; inj site reactions.
MIMS Class
Trophic Hormones & Related Synthetic Drugs
ATC Classification
G03GA08 - choriogonadotropin alfa ; Belongs to the class of gonadotropins. Used as ovulation stimulants.
Presentation/Packing
Form
Ovidrel inj 250 mcg/0.5 mL
Packing/Price
0.5 mL x 1's
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