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Levodopa (L-Dopa): The effect of L-dopa may be reduced when vitamin B6 is administered concomitantly.
Pyridoxine-Antagonists eg, Isoniazid (INH), Cycloserin, Penicillamin, Hydralazine: The efficacy of vitamin B6 (pyridoxine) may be decreased.
Loop Diuretics eg, Furosemide: In long-term use, the blood level of thiamine may be reduced.
Long term use of acid lowering agent may lead to Vitamin B12 deficiency.
