Discontinue use at 1st appearance of skin rash, mucosal lesions or any other sign of hypersensitivity. Patients w/ history of GI disease. Monitor patients w/ GI symptoms. W/draw use if GI ulceration or bleeding occurs. Patients receiving treatment w/ anticoagulants. Patients w/ CV disease or its risk factors. May precipitate overt renal decompensation which is typically followed by recovery to pre-treatment state upon discontinuation of NSAID therapy. Dehydrated patients, those w/ CHF, liver cirrhosis, nephrotic syndrome & overt renal disease, those receiving concomitant treatment w/ diuretic, ACE inhibitor or AIIA or those having undergone major surgical procedures which led to hypovolaemia. Discontinue use if abnormalities (eg, elevated serum transaminases or other liver function parameters) is significant or persistent. Carefully supervise frail or debilitated patients. Induction of Na, K & water retention & interference w/ natriuretic effects of diuretics may occur. May precipitate or exacerbate cardiac failure or HTN in susceptible patients; clinical monitoring is recommended. May mask symptoms of underlying infectious disease. Not to be taken by patients w/ rare hereditary problems of galactose intolerance, the Lapp-lactase deficiency or glucose-galactose malabsorption. Avoid potentially hazardous tasks (eg, driving or operating machinery) if patient experiences visual disturbance including blurred vision, dizziness, somnolence, vertigo & other CNS disturbances. May impair fertility; not recommended in women attempting to conceive. Consider treatment w/drawal in women who have difficulties conceiving or who are undergoing infertility investigation. Adolescent. Elderly.
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