Micardis

Telmisartan

Essential HTN in adults. Risk reduction of non-fatal stroke or MI in adults ≥55 yr at high risk of developing major CV events who cannot tolerate ACE inhibitors. High risk of CV events include evidence of CAD, peripheral arterial disease, stroke, transient ischemic attack or DM w/ evidence of end-organ damage.

Adult Essential HTN 40 mg once daily. Max: 80 mg once daily. May be used in combination w/ thiazide-type diuretics eg, hydrochlorothiazide or Ca-channel blockers (eg, amlodipine). Severe HTN Up to 160 mg alone or in combination w/ hydrochlorothiazide 12.5-25 mg daily. Reduction of CV morbidity 80 mg once daily. BP monitoring is recommended & if appropriate, adjustment of medications that lower BP may be necessary. Mild to moderate hepatic impairment Max: 40 mg once daily.

May be taken with or without food.

Hypersensitivity. Biliary obstructive disorders. Severe hepatic impairment. Concomitant use w/ aliskiren in patients w/ DM or renal impairment (GFR <60 mL/min/1.73 m²). Pregnancy (2nd & 3rd trimesters) & lactation.

Possible hyperkalaemia especially in the presence of renal impairment &/or heart failure; monitor serum K. Concomitant use w/ K-sparing diuretics, K supplements, K-containing salt substitutes or other medical products that may increase K level (eg, heparin). Symptomatic hypotension especially after the 1st dose, may occur in patients who are vol &/or Na depleted by vigorous diuretic therapy, dietary salt restriction, diarrhoea or vomiting. Increased risk of severe hypotension & renal insufficiency when patients w/ bilateral renal artery stenosis or stenosis of the artery to a single functioning kidney are treated w/ medical products that affect the renin-angiotensin-aldosterone system (RAAS). Periodic monitoring of serum K & creatinine in patients w/ impaired renal function. Not to be used concomitantly w/ ACE-inhibitors & ARBs in patients w/ diabetic nephropathy. Patients whose vascular tone & renal function depend predominantly on the RAAS activity. Not recommended in patients w/ primary aldosteronism. Patients suffering from aortic or mitral stenosis or obstructive hypertrophic cardiomyopathy. Increased risk of fatal MI & unexpected CV death when treated w/ BP lowering agents (eg, ARBs or ACE-inhibitors) in diabetics w/ additional CV risk (ie, patients w/ DM & coexistent CAD). Patients w/ ischaemic cardiopathy or CV disease. Contains sorbitol. Not for patients w/ rare hereditary condition of fructose intolerance. May affect ability to drive & use machines due to occasional syncope or vertigo. Patients w/ biliary obstructive disorder or hepatic insufficiency. May be less effective in lowering BP in Black people than in non-Blacks. Childn <18 yr.

Sepsis (including fatal outcome), URTI, UTI, cystitis; thrombocytopenia, anaemia, eosinophilia; anaphylactic reaction, hypersensitivity; hyperkalaemia, hypoglycaemia (in diabetics), hyponatraemia; depression, anxiety, insomnia; syncope; visual impairment; vertigo; bradycardia, tachycardia; hypotension, orthostatic hypotension; dyspnoea; abdominal pain, diarrhoea, vomiting, dyspepsia, dry mouth, flatulence, abdominal discomfort; abnormal hepatic function/liver disorder; angioedema (including fatal outcome), drug eruption, toxic skin eruption, urticaria, eczema, erythema, rash, pruritus, hyperhidrosis; arthralgia, back pain, pain in extremity, tendon pain, muscle spasms, myalgia; renal impairment including acute kidney injury; chest pain, asthenia, flu-like illness; increased hepatic enzymes, blood creatinine, blood creatine phosphokinase & blood uric acid & decreased Hb.

May increase hypotensive effects of other antihypertensive agents. Increase in digoxin median plasma. Reversible increases in serum lithium conc & toxicity. Potential for acute renal insufficiency in dehydrated patients in concomitant use w/ NSAIDs. Higher frequency of adverse events [eg, hypotension, hyperkalaemia & decreased renal function (including acute renal failure)] in combined use of ACE-inhibitors, ARBs or aliskiren.

Angiotensin II Antagonists

C09CA07 - telmisartan ; Belongs to the class of angiotensin II receptor blockers (ARBs). Used in the treatment of cardiovascular disease.

POM