Adult Acute exacerbations of OA 7.5 mg daily, may increase to 15 mg daily if necessary. RA & ankylosing spondylitis 15 mg daily. Patient at increased risk for AR Initially 7.5 mg daily. Patient w/ severe renal failure undergoing dialysis Max dose: 7.5 mg daily. Elderly being treated for RA Recommended dose (long term): 7.5 mg daily.
View Melox overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food: May be taken w/ meals if GI discomfort occurs.
Contraindications
Hypersensitivity to meloxicam; possible cross sensitivity w/ other NSAIDs or aspirin. Patients who developed asthma, nasal polyps, angioneurotic oedema, urticaria or any other hypersensitivity reaction following administration of any NSAIDs or aspirin. Active peptic ulcer or history of recurrent PUD. Cerebrovascular or GI bleeding or any other bleeding disorder. Severe hepatic or renal impairment w/o dialysis.
Check for history of oesophagitis, gastritis, or peptic ulcer before initiating therapy. Monitor for digestive disturbances & GI bleeding or ulceration &/or perforation in patients w/ GI or a history of GI disease. Consider w/drawal in the event of severe cutaneous or mucosal adverse effects. Possible glomerulonephritis, interstitial nephritis, nephritic syndrome or renal medullary necrosis; increased serum transaminase level, serum bilirubin, other liver function parameters, serum creatinine, BUN & other laboratory test disturbances. May cause Na, K & water retention; may interfere w/ natriuretic effects of diuretics. Patients w/ decreased renal blood flow & blood vol. May cause latent renal failure decompensation in elderly, patients w/ CHF, cirrhosis, nephritic syndrome, renal failure. Patients who have undergone major surgery resulting in hypovolaemia or on diuretic therapy. Monitor diuresis & renal function during therapy. Patients may experience drowsiness, vertigo, visual & other CNS disturbances; advise not to drive or operate machinery if such disturbances occur. Avoid use during pregnancy; absolutely contraindicated during the final trimester. Avoid in breast feeding women. Childn <15 yr. Elderly (particularly those who have cardiac, renal or hepatic impairment), fragile or weakened patient.
Increased risk of GI ulceration &/or bleeding w/ other NSAIDs & high dose salicylates. Increased blood lithium levels. Increased risk of bleeding w/ oral anticoagulants, ticlopidine, parenteral heparin; pentoxifylline. Decreased renal clearance of methotrexate. May enhance nephrotoxicity of cyclosporin. Elevated risk of acute renal failure in dehydrated patients w/ diuretics. Increased risk of greater red cell line toxicity effects w/ zidovudine. Decreased effects of antihypertensives (eg, β-blockers, ACE inhibitors, diuretics). Possible risk of impaired efficacy of IUD. Elevated risk of bleeding w/ thrombolytics. Accelerated elimination by cholestyramine.
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