Adult Vag candidiasis 150 mg as a single oral dose.
Oropharyngeal candidiasis 50 mg once daily for 7-14 days; treat longer in severely immunocompromised patients.
Atrophic oral candidiasis 50 mg once daily for 14 days.
Oesophagitis, non-invasive bronchopulmonary infection, mucocutaneous candidiasis & candiduria 50 mg once daily for 14-30 days, may be increased to 100 mg for difficult mucosal candidal infections.
Tinea pedis, tinea cruris, tinea corporis, tinea versicolor & dermal Candida infection 50 mg once daily for 2-4 wk. Tinea pedis may require treatment for up to 6 wk.
Candidaemia, disseminated candidiasis & invasive candidal infections Initially 400 mg on the 1st day followed by 200 mg once daily. If required, may be increased to 400 mg once daily.
Cryptococcal meningitis & other cryptococcal infections Initially 400 mg on the 1st day followed by 200-400 mg once daily, usually 6-8 wk.
Prevention of relapse of cryptococcal meningitis in AIDS patient 100-200 mg once daily.
Prevention of fungal infection in immunocompromised patient at risk due to neutropenia consequent upon cytotoxic chemotherapy or radiotherapy 50-400 mg once daily.
High risk patient eg, bone marrow transplants 400 mg once daily. Dosage should be initiated several days before the anticipated onset of neutropenia & should be continued for 7 days after neutrophil count >1,000 cells/mm
3.
Childn >4 wk Mucosal candidiasis 3 mg/kg once daily. A loading dose of 6 mg/kg may be given on the 1st day to rapidly achieve steady state.
Systemic candidiasis & cryptococcal infections 6-12 mg/kg once daily depending upon severity of infection.
Prevention of fungal infection in immunocompromised patient at risk as a consequence of induced neutropenia 3-12 mg/kg depending upon extent & duration of neutropenia.
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