Hypersensitivity to ceftriaxone, to any other cephalosporin or to any of the excipients listed in Description.
History of severe hypersensitivity (e.g. anaphylactic reaction) to any other type of beta-lactam antibacterial agent (penicillins, monobactams and carbapenems).
Ceftriaxone is contraindicated in: Premature neonates up to a postmenstrual age of 41 weeks (gestational age + chronological age)*.
Full-term neonates (up to 28 days of age): with hyperbilirubinemia, jaundice, or who are hypoalbuminaemic or acidotic because these are conditions in which bilirubin binding is likely to be impaired*; if they require (or are expected to require) intravenous calcium treatment, or calcium-containing infusions due to the risk of precipitation of a ceftriaxone calcium salt (see Precautions, Adverse Reactions and Incompatibilities under Cautions for Usage).
*In vitro studies have shown that ceftriaxone can displace bilirubin from its serum albumin binding sites leading to a possible risk of bilirubin encephalopathy in these patients.
Contraindications to lidocaine must be excluded before intramuscular injection of ceftriaxone when lidocaine solution is used as a solvent (see Precautions).
Ceftriaxone solutions containing lidocaine should never be administered intravenously.