Recommended dose: 25 mg/m
2 bd (approx every 12 hr). Individualised dosing based on BSA. Max single dose: 50 mg.
≥1.90 m2 50 mg bd,
1.70-1.89 m2 45 mg bd,
1.50-1.69 m2 40 mg bd,
1.30-1.49 m2 35 mg bd,
1.10-1.29 m2 30 mg bd,
0.90-1.09 m2 25 mg bd,
0.70-0.89 m2 20 mg bd,
0.55-0.69 m2 20 mg in the morning & 10 mg in the evening. Continue treatment as long as clinical benefit is observed or until PN progression or unacceptable toxicity develops.
Dose adjustments for adverse events: ≥1.90 m2 1st dose reduction: 35 mg in the morning & evening. 2nd dose reduction: 25 mg in the morning & evening,
1.70-1.89 m2 1st dose reduction: 35 mg in the morning & 30 mg in the evening. 2nd dose reduction: 25 mg in the morning & 20 mg in the evening,
1.50-1.69 m2 1st dose reduction: 30 mg in the morning & evening. 2nd dose reduction: 25 mg in the morning & 20 mg in the evening,
1.30-1.49 m2 1st dose reduction: 25 mg in the morning & evening. 2nd dose reduction: 25 mg in the morning & 10 mg in the evening,
1.10-1.29 m2 1st dose reduction: 25 mg in the morning & 20 mg in the evening. 2nd dose reduction: 20 mg in the morning & 10 mg in the evening,
0.90-1.09 m2 1st dose reduction: 25 mg in the morning & 10 mg in the evening. 2nd dose reduction: 10 mg in the morning & evening,
0.70-0.89 m2 1st dose reduction: 20 mg in the morning & 10 mg in the evening. 2nd dose reduction: 10 mg in the morning & evening,
0.55-0.69 m2 1st dose reduction: 10 mg in the morning & evening. 2nd dose reduction: 10 mg once daily.
Co-administration w/ CYP3A4 or CYP2C19 inhibitors Individualised dosing based on BSA. Reduce dose to 20 mg/m
2 bd if patient is currently taking 25 mg/m
2 bd. Reduce dose to 15 mg/m
2 bd if patient is currently taking 20 mg/m
2 bd.
Moderate hepatic impairment Starting dose: 20 mg/m
2 bd.