Cerebrovascular and peripheral vascular disease
Adult: 10-20 mg 3 or 4 times daily.
Indications and Dosage
Oral
Cerebrovascular and peripheral vascular disease Adult: 10-20 mg 3 or 4 times daily.
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Administration
May be taken with or without food. May be taken w/ meals, milk or antacids to minimise GI discomfort.
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Contraindications
Recent arterial haemorrhage.
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Special Precautions
Pregnancy and lactation. Not intended to be given immediately postpartum.
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Adverse Reactions
Significant: Severe rash.
Nervous: Trembling, nervousness, weakness, dizziness. CV: Palpitation, tachycardia, chest pain, hypotension, flushing. GI: Abdominal distress, nausea, vomiting, intestinal distention. |
IV/Parenteral/PO: C
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Action
Description:
Mechanism of Action: Isoxsuprine, a β-agonist, increases muscle blood flow by directly relaxing the vascular smooth muscle. Pharmacokinetics: Absorption: Well absorbed from the GI tract. Time to peak plasma concentration: Approx 1 hr. Distribution: Crosses the placenta. Excretion: Excreted via urine as conjugates. Plasma elimination half-life: Approx 1.5 hr. |
Chemical Structure
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Storage
Store between 15-30°C.
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ATC Classification
C04AA01 - isoxsuprine ; Belongs to the class of 2-amino-1-phenylethanol derivative agents. Used as peripheral vasodilators.
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References
Anon. Isoxsuprine. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 10/07/2017. Buckingham R (ed). Isoxsuprine Hydrochloride. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 10/07/2017. Isoxsuprine Hydrochloride Tablets (Vista Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 10/07/2017. McEvoy GK, Snow EK, Miller J et al (eds). Isoxsuprine Hydrochloride. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 10/07/2017.
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