Moderate to severe infections caused by susceptible microorganism strains as well as initial empiric therapy prior to the identification of causative organisms in complicated intra-abdominal infections; complicated skin & skin structure infections including diabetic lower extremity infections; community-acquired pneumonia; complicated UTI including pyelonephritis; acute pelvic infections including postpartum endomyometritis, septic abortion & post-surgical gynecologic infections. Prophylaxis of surgical site infection following elective colorectal surgery in adults.
Patient ≥13 yr 1 g once daily for 3-14 days by IV infusion over 30 min or IM inj. Patient 3 mth to 12 yr 15 mg/kg bd for 3-14 days by IV infusion over 30 min or IM inj. Max: 1 g daily. Prophylaxis of surgical site infection following elective colorectal surgeryAdult 1 g as a single IV dose given 1 hr prior to surgical incision. Advanced renal insufficiency (CrCl ≤30 mL/min/1.73 m2) including those on hemodialysis 500 mg daily. If 500 mg is given w/in 6-hr prior to hemodialysis, a supplementary dose of 150 mg is recommended following hemodialysis session.
Immediately discontinue use if an allergic reaction occurs. Previous hypersensitivity reactions to penicillins, cephalosporins, other β-lactams & other allergens. Not recommended in concomitant use w/ valproic acid/divalproex Na. Possible seizures & other CNS adverse experiences in patients w/ CNS disorders (eg, brain lesions, history of seizures) &/or compromised renal function; known predisposing factors to convulsive activity. Evaluate patients neurologically if focal tremors, myoclonus or seizures occur. Prolonged use may result in overgrowth of non-susceptible organisms; take appropriate measures if superinfection occurs during therapy. Consider diagnosis of pseudomembranous colitis in patients who present w/ diarrhea following therapy. Avoid inadvertent inj into blood vessels when administering intramuscularly. Lidocaine HCl is the diluent for IM administration. Patients could be exposed to suboptimal ertapenem conc & consequently to a risk of potential treatment failure in cases of surgical interventions >4 hr. Should only be used to treat/prevent proven or strongly suspected infections caused by susceptible bacteria to reduce drug resistance development & maintain Invanz effectiveness. Pregnancy & lactation. Not recommended for meningitis in ped population; renal insufficiency. Not recommended in infant <3 mth.
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