Adult, adolescent & childn (≥30 kg) Initially 400 mg daily dose, may be increased by 400 mg/day as frequently as every 2 days. Max: ≥70.1 kg 3,200 mg/day; 50.1-70 kg 2,400 mg/day; 30-50 kg 1,800 mg/day. Adult & childn (<30 kg) Initially 200 mg daily, may be increased by 200 mg/day increments as frequently as every 2 days. Max: 1,000 mg/day; patient taking valproate Initially 200 mg daily dose. After a min of 2 days, dose may be increased by 200 mg/day. Max: 600 mg/day.
Status epilepticus. W/draw gradually to reduce the possibility of seizures on w/drawal. Associated w/ dizziness, somnolence, ataxia & gait disturbances. Serious antiepileptic drug hypersensitivity syndrome including drug reaction w/ eosinophilia & systemic symptoms (DRESS) & Stevens-Johnson syndrome. Lymphadenopathy, liver function test abnormalities & hematuria. Discontinue use & start alternative treatment if antiepileptic drug hypersensitivity syndrome is suspected. Decreased in QTc interval proportional to conc. Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Monitor for signs of suicidal ideation & behaviour. Mild to moderate hepatic impairment. Not recommended in patients w/ severe hepatic impairment. May influence the ability to drive or operate machinery. Women of childbearing potential must use effective contraception during treatment. Pregnancy & lactation. Elderly >65 yr. Newborn infants or infants & toddlers <2 yr.
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