Not recommended for patients w/ type 1 diabetes or for diabetic ketoacidosis. Immediately assess for ketoacidosis if symptoms (eg, nausea, vomiting, anorexia, abdominal pain, excessive thirst, difficulty breathing, confusion, unusual fatigue, sleepiness) occur. Consider monitoring of ketones even if treatment has been interrupted. Discontinue use if ketoacidosis; necrotizing fasciitis of the perineum (Fournier's gangrene); bullous pemphigoid are suspected. Patients w/ history of pancreatitis. Discontinue use if pancreatitis is suspected; do not restart if acute pancreatitis is confirmed. May lead to a modest BP decrease. Patients w/ known CV disease; those on antihypertensive therapy w/ history of hypotension. Carefully monitor vol status & electrolytes in case of conditions that may lead to fluid loss (eg, GI illness). Consider temporary treatment interruption in patients w/ complicated UTI. Combination w/ sulphonylurea or insulin. Do not initiate in patients w/ & discontinue use if eGFR is persistently <45 mL/min/1.73 m
2. Assess renal function prior to initiation of treatment & periodically during treatment. Not recommended in patients w/ severe hepatic impairment. Possible hepatic injury. Pregnancy. Discontinue breastfeeding during treatment. Not recommended in childn <18 yr. Elderly ≥75 yr.