Long-term androgen deprivation therapy may prolong QT interval. History of corrected QT interval >450 millisec, torsades de pointes. Concomitant use w/ medicine that prolong QT interval. History of severe untreated asthma, anaphylactic reactions or severe urticaria or angioedema. Decreased bone density. Glucose tolerance. CV disease eg, stroke, MI. Patients w/ known or suspected hepatic disorder & severe renal impairment. Fatigue & dizziness that might influence the ability to drive or operate machinery. May inhibit male fertility.
Concomitant use w/ drugs known to prolong the QTc interval or induce torsades de pointes [eg, class IA (eg, quinidine, disopyramide) or class III (eg, amiodarone, sotalol, dofetilide, ibutilide)], antiarrhythmics, methadone, cisapride, moxifloxacin, antipsychotics.
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