Etoricoxib is contra-indicated in: patients with known hypersensitivity to etoricoxib or to any of the excipients of this medicinal product; patients with congestive heart failure (NYHA II-IV); patients with established ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease (including patients who have recently undergone coronary artery bypass graft surgery or angioplasty); patients with hypertension whose blood pressure has not been adequately controlled; patients with active peptic ulceration or gastro-intestinal (GI) bleeding; patients with severe hepatic dysfunction (Child-Pugh score >9); patients with estimated creatinine clearance <30 ml/min; patients who have developed signs of asthma, acute rhinitis, nasal polyps, angioneurotic oedema or urticaria following the administration of acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs); pregnancy and lactation (see Use in Pregnancy & Lactation and Pharmacology: Toxicology: Preclinical safety data under Actions); children and adolescents under 16 years of age; patients with inflammatory bowel disease.