IV (as bolus inj or continuous infusion). Individualized dosing.
Surgical procedures: Tracheal intubation Routine anesth: 0.6 mg/kg. Rapid sequence induction: 1 mg/kg; during cesarean section: 0.6 mg/kg.
Maintenance Recommended dose: 0.15 mg/kg. Long-term inhalational anesth: Reduce dose to 0.075-0.1 mg/kg. Maintenance doses should best be given when twitch height has recovered to 25% of control twitch height, or when 2-3 responses to train of 4 stimulation are present.
Continuous infusion Loading dose: 0.6 mg/kg. Infusion rate: Adjust to maintain twitch response at 10% of control twitch height or to maintain 1-2 responses to train of 4 stimulation.
Geriatric & patient w/ hepatic & biliary tract disease &/or renal failure Routine anesth/rapid sequence induction: 0.6 mg/kg. Maintenance: 0.075-0.1 mg/kg. Infusion rate: 0.3-0.4 mg/kg/hr.
Intensive care procedures: Tracheal intubation Routine anesth: 0.6 mg/kg. Rapid sequence induction: 1 mg/kg.
Maintenance Loading dose: 0.6 mg/kg followed by continuous infusion as soon as twitch height recovers to 10% or upon reappearance of 1-2 twitches to train of 4 stimulation. Infusion rate: Initially 0.3-0.6 mg/kg/hr during the 1st hr of administration to be decreased during the following 6-12 hr according to the individual response.