Erbitux Caution For Usage

Incompatibilities: This medicinal product must not be mixed with other medicinal products except those mentioned in Special precautions for disposal and other handling as follows.
A separate infusion line must be used.
Special precautions for disposal and other handling: Erbitux may be administered via a gravity drip, an infusion pump or a syringe pump. A separate infusion line must be used for the infusion, and the line must be flushed with sterile sodium chloride 9 mg/ml (0.9%) solution for injection at the end of infusion.
Erbitux 5 mg/ml is compatible: with PE (polyethylene), EVA (ethyl vinyl acetate) or PVC (polyvinyl chloride) bags; with PE, EVA, PVC, TP (polyolefine thermoplast) or PUR (polyurethane) infusion sets; with PP (polypropylene) syringes for syringe pump.
Care must be taken to ensure aseptic handling when preparing the infusion.
Erbitux 5 mg/ml must be prepared as follows: For administration with infusion pump or gravity drip (diluted with sterile sodium chloride 9 mg/ml (0.9%) solution): Take an infusion bag of adequate size of sterile sodium chloride 9 mg/ml (0.9%) solution. Calculate the required volume of Erbitux. Remove an adequate volume of the sodium chloride solution from the infusion bag, using an appropriate sterile syringe with a suitable needle. Take an appropriate sterile syringe and attach a suitable needle. Draw up the required volume of Erbitux from a vial. Transfer Erbitux into the prepared infusion bag. Repeat this procedure until the calculated volume has been reached. Connect the infusion line and prime it with the diluted Erbitux before starting the infusion. Use a gravity drip or an infusion pump for administration. Set and control the rate as explained in Dosage & Administration.
For administration with an infusion pump or gravity drip (undiluted): Calculate the required volume of Erbitux. Take an appropriate sterile syringe (minimum 50 ml) and attach a suitable needle. Draw up the required volume of Erbitux from a vial. Transfer Erbitux into a sterile evacuated container or bag. Repeat this procedure until the calculated volume has been reached. Connect the infusion line and prime it with Erbitux before starting the infusion. Use a gravity drip or an infusion pump for administration. Set and control the rate as explained previously.
For administration with a syringe pump: Calculate the required volume of Erbitux. Take an appropriate sterile syringe and attach a suitable needle. Draw up the required volume of Erbitux from a vial. Remove the needle and put the syringe into the syringe pump. Connect the infusion line to the syringe, set and control the rate as explained in Dosage & Administration and start the infusion after priming the line with Erbitux or sterile sodium chloride 9 mg/ml (0.9%) solution. If necessary, repeat this procedure until the calculated volume has been infused.