Diflorasone: Indication, Dosage, Side Effect, Precaution

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Singapore prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Corticosteroid-responsive dermatoses

Adult: As 0.05% oint/cream: Apply a thin film onto the affected areas 1-4 times daily depending on the severity of the condition.

Contraindications

As treatment for rosacea or perioral dermatitis.

Special Precautions

Pregnancy and lactation.

Adverse Reactions

Significant: HPA axis suppression, manifestations of Cushing’s syndrome, hyperglycaemia, and glycosuria.
Dermatologic: Itching, burning, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration, atrophy, striae, miliaria, secondary infections.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Do not apply on the face, eyes, mucous membranes, intertriginous areas, occluded or broken skin, and into a large surface area.

Monitoring Parameters

Monitor for hypothalamic-pituitary adrenal (HPA) axis suppression through ACTH stimulation test, plasma cortisol test, or urinary free cortisol test.

Action

Description:
Mechanism of Action: Diflorasone is a glucocorticoid that has anti-inflammatory, antipruritic, and vasoconstrictive actions. It induces phospholipase A₂ inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid, hence depresses the formation, release, and activity of chemical inflammatory mediators.
Pharmacokinetics:
Absorption: Absorbed through normal intact skin (approx 1%); increased percutaneous absorption in inflamed or occluded skin.
Metabolism: Metabolised in the liver.
Excretion: Via urine and faeces.

Chemical Structure

Storage

Store between 20-25°C.

MIMS Class

Topical Corticosteroids

ATC Classification

D07AC10 - diflorasone ; Belongs to the class of potent (group III) corticosteroids. Used in the treatment of dermatological diseases.

References

Anon. Diflorasone. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 16/02/2017.

Buckingham R (ed). Diflorasone Diacetate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 16/02/2017.

Diflorasone Diacetate Cream (E. Fougera & Co. A division of Fougera Pharmaceuticals Inc). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 16/02/2017.

McEvoy GK, Snow EK, Miller J et al (eds). Dilforasone Diacetate (Topical). AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 16/02/2017.

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